AcroSeal Packaging


The AcroSeal system: performance, convenience, safety

Chemical reactions often involve the use of air- and moisture-sensitive solvents, pyrophoric and hazardous reagents. Our AcroSeal™ packaging is an industry-leading packaging solution for safer handling of these types of materials, which are used in drug discovery, agrochemical research, flavors and fragrances, diagnostics, NMR analysis and other applications.

If you are new to AcroSeal Packaging, please see "How to use AcroSeal packaging" below.

The new AcroSeal cap

What's changing?

We have recently improved our AcroSeal packaging. The redesigned gray portion of the sealing system makes it both easier and safer to remove the whole system and replace it back on the bottle securely. No special tool is required for removal or replacement. This facilitates access to larger volumes of product and packaging recycling after use.




Frequently asked questions about our updated AcroSeal packaging

Why are we making these changes?

The redesigned gray portion of the sealing system makes it both easier to remove the whole system and replace it back on the bottle. No special tool is required for removal or replacement. It also makes it more difficult to accidentally unscrew the whole sealing system.

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Why is it important that the whole sealing system can be removed?

In use, removal of the whole system allows access to higher volumes of dry solvent than the usual method of multiple needle and syringe extractions. Simply decant from the bottle in dry conditions (i.e., in the fume hood). It is essential that the complete system be securely replaced if material remains for later use.

After use, the new design simplifies recycling that requires separation of the glass bottle from the plastic cap.

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Is there a change to the septum?

No, the septum is not changing.

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When will I see the new cap on Alfa Aesar and Acros Organics products in my lab?

Products will begin shipping with the new AcroSeal cap during late July and August 2019, starting with deuterated products, followed by popular organometallics and reagents in solution, and then dry solvents later in the year.

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How has it been made more difficult to accidentally remove the whole system from the bottle?

There is now a clear distinction in the system between the red cap to be removed for ‘regular’ use and the gray collar.

A second tamper-evident ring has been added to protect against accidental removal as the second seal must be deliberately broken to remove the whole gray collar and red cap together.

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How to use AcroSeal packaging


To get the best results using AcroSeal packaging, we recommend the following process:

1. Puncture the septum

2. Withdraw the required amount

3. Replace the nitrogen blanket

4. Store upright to prevent prolonged product contact with the seal

Advanced tips:

  1. Prepare the nitrogen balloon in advance and use two balloons, one inside the other
  2. Purge the doubled balloons with nitrogen three times before use
  3. Bend the needle as it makes it easier to use and control
  4. Flush each needle and syringe with nitrogen three times before use
  5. Use the reaction flask to flush the syringe and needle prior to use

To get the best results from the septum, we recommend you use 18 to 21 gauge needles and puncture in a clock face pattern to avoid piercing the septum in the same place.

If you require a large amount of solvent, remove the whole cap under an inert atmosphere and decant the desired amount of product from the bottle.

For further tips on how to use AcroSeal packaged products, view our demonstration videos below:

AcroSeal packaging applications

Grignard reagents

Our AcroSeal-packaged Grignard reagents ensure the exclusion of air and moisture from Grignard reaction conditions for carbon-carbon bond formation.

Alkyllithium reagents

We offer a wide selection of AcroSeal-packaged organolithium compounds for reactions such as transmetallation and nucleophilic addition and substitution.

Metal hydrides

Our AcroSeal-packaged hydrides, extremely pyrophoric reducing agents, can be used safely in the reduction of esters, carboxylic acids and amides.

Dry Solvents

When using air- and moisture-sensitive solvents and reagents, it is essential that these products are not only as dry as possible when you first use them, but they should remain dry in storage as well.